According to a new study published in the journal Discomfort Management, the presence of THC metabolites in the urine of sufferers undergoing discomfort management is linked with reduced levels of opioids.
For the study, researchers analyzed around 800,000 urine drug test outcomes collected from discomfort management sufferers involving the years 2016 and 2018.
The study states that “For every of the eight opioids monitored, reduced imply concentrations have been observed when THC-COOH [the primary metabolite of THC] was also present in the sample. The variations in opioid concentrations involving the THC good and THC damaging groups have been statistically important … The biggest shift was observed in codeine good samples, followed by morphine, and fentanyl. … The buprenorphine good group had the highest percentage of samples containing THC (20.eight %), and hydrocodone had the lowest THC good price, 9.two %.”
Whilst researchers acknowledged that the findings have been “consistent with information from self-report surveys of health-related cannabis patients” in which subjects often report substituting cannabis for opioids, they cautioned that the observational style of the study precluded them from “assigning causation” to their outcomes, reports NORML.
They concluded: “Further research will hopefully elucidate if cannabis can or ought to play a function in discomfort management via the anti-nociceptive properties of THC and any prospective interaction with opioids. From the point of view of opioid addiction remedy, it is fascinating that the highest price of THC use was observed in buprenorphine-good samples as buprenorphine is often utilized as a element of medication-assisted remedy for opioid dependence. Additional research are also required to identify if THC/cannabis use alone or in mixture with other health-related remedies might aid combat OUD (opioid use disorder).”
The complete text of the study is titled “Reduced opioid levels from discomfort management sufferers linked with marijuana use”. The complete abstract of the study can be discovered beneath:
Aim: Marijuana use has been postulated to modulate opioid use, dependence, and withdrawal. Broad target drug testing outcomes present a exceptional point of view to determine any prospective interaction involving marijuana use and opioid use. Supplies & solutions: Working with a dataset of around 800,000 urine drug test outcomes collected from discomfort management sufferers of time from of various years, creatinine corrected opioid levels have been evaluated to identify if the presence of the main marijuana marker 11-nor-carboxy-tetrahydrocannabinol (THC-COOH) was linked with statistical variations in excreted opioid concentrations. Benefits & conclusion: For every of the opioids investigated (codeine, morphine, hydrocodone, hydromorphone, oxycodone, oxymorphone, fentanyl and buprenorphine), marijuana use was linked with statistically important reduced urinary opiate levels than in samples without having indicators of marijuana use.